NPR1
Gene Information
- Official Symbol: NPR1
- Official Name: natriuretic peptide receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4881
- UniProt: P16066
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. {ECO:0000269|PubMed:1672777}.
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
| Guanylate cyc |
| ANF receptor |
GO Terms
| natriuretic peptide receptor activity |
| peptide receptor activity |
| positive regulation of cGMP-mediated signaling |
| guanylate cyclase activity |
| receptor guanylyl cyclase signaling pathway |
| hormone binding |
| cGMP biosynthetic process |
| positive regulation of renal sodium excretion |
| regulation of cGMP-mediated signaling |
| positive regulation of urine volume |
| cGMP metabolic process |
| regulation of renal sodium excretion |
| regulation of urine volume |
| cyclic nucleotide biosynthetic process |
| cyclic purine nucleotide metabolic process |
| regulation of excretion |
| cGMP-mediated signaling |
| dopamine metabolic process |
| regulation of renal system process |
| regulation of vascular permeability |
| peptide hormone binding |
| G protein-coupled peptide receptor activity |
| cyclic nucleotide metabolic process |
| catechol-containing compound metabolic process |
| catecholamine metabolic process |
| negative regulation of smooth muscle cell proliferation |
| regulation of cardiac conduction |
| body fluid secretion |
| phenol-containing compound metabolic process |
| negative regulation of angiogenesis |
| negative regulation of blood vessel morphogenesis |
| renal system process |
| negative regulation of vasculature development |
| regulation of smooth muscle cell proliferation |
| regulation of blood vessel diameter |
| regulation of tube diameter |
| regulation of tube size |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| vascular process in circulatory system |
| purine-containing compound biosynthetic process |
| cyclic-nucleotide-mediated signaling |
| regulation of blood pressure |
| negative regulation of cell growth |
| ammonium ion metabolic process |
| receptor complex |
| protein kinase activity |
| regulation of heart contraction |
| negative regulation of growth |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| regulation of angiogenesis |
| regulation of blood circulation |
| purine ribonucleotide metabolic process |
| regulation of vasculature development |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| second-messenger-mediated signaling |
| purine-containing compound metabolic process |
| GTP binding |
| blood circulation |
| circulatory system process |
| regulation of cell growth |
| positive regulation of secretion |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic hydroxy compound metabolic process |
| protein kinase binding |
| regulation of body fluid levels |
| drug metabolic process |
| regulation of anatomical structure size |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| regulation of system process |
| carbohydrate derivative biosynthetic process |
| regulation of growth |
| negative regulation of cell population proliferation |
| enzyme linked receptor protein signaling pathway |
| regulation of secretion |
| organophosphate metabolic process |
| negative regulation of developmental process |
| protein phosphorylation |
| positive regulation of transport |
| positive regulation of intracellular signal transduction |
| carbohydrate derivative metabolic process |
| regulation of anatomical structure morphogenesis |
| nucleobase-containing compound biosynthetic process |
| secretion |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| organonitrogen compound biosynthetic process |
| ATP binding |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Phorbol-12-myristate-13-acetate 0.57μM R08 exp514 | -1.95 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8356
- Expression level (log2 read counts): -3.51
Expression Distribution
NPR1 Expression in NALM6 Cells: -3.51
