PAX8
Gene Information
- Official Symbol: PAX8
- Official Name: paired box 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 7849
- UniProt: Q06710
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010].
- UniProt Summary: Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.
Pfam Domains GO Terms
Pfam Domains
| PAX |
| Pax2 C |
GO Terms
| regulation of thyroid-stimulating hormone secretion |
| positive regulation of metanephric DCT cell differentiation |
| negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis |
| thyroid-stimulating hormone receptor activity |
| thyroid-stimulating hormone signaling pathway |
| regulation of metanephric DCT cell differentiation |
| regulation of apoptotic process involved in metanephric nephron tubule development |
| pronephric field specification |
| negative regulation of apoptotic process involved in metanephric nephron tubule development |
| negative regulation of apoptotic process involved in metanephric collecting duct development |
| regulation of apoptotic process involved in metanephric collecting duct development |
| pattern specification involved in pronephros development |
| kidney field specification |
| regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis |
| regulation of mesenchymal cell apoptotic process involved in metanephros development |
| metanephric comma-shaped body morphogenesis |
| positive regulation of thyroid hormone generation |
| kidney rudiment formation |
| negative regulation of mesenchymal cell apoptotic process involved in metanephros development |
| regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| negative regulation of somatic stem cell population maintenance |
| negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| metanephric nephron tubule formation |
| regulation of thyroid hormone generation |
| comma-shaped body morphogenesis |
| metanephric distal convoluted tubule development |
| distal convoluted tubule development |
| metanephric S-shaped body morphogenesis |
| negative regulation of apoptotic process involved in morphogenesis |
| negative regulation of apoptotic process involved in development |
| metanephric tubule formation |
| regulation of somatic stem cell population maintenance |
| negative regulation of stem cell population maintenance |
| S-shaped body morphogenesis |
| mesenchymal to epithelial transition involved in metanephros morphogenesis |
| regulation of metanephric nephron tubule epithelial cell differentiation |
| metanephric distal tubule development |
| positive regulation of epithelial cell differentiation involved in kidney development |
| metanephric nephron tubule morphogenesis |
| regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| pronephros development |
| renal system pattern specification |
| pattern specification involved in kidney development |
| negative regulation of metanephros development |
| negative regulation of mesenchymal cell apoptotic process |
| metanephric renal vesicle morphogenesis |
| metanephric tubule morphogenesis |
| regulation of apoptotic process involved in development |
| distal tubule development |
| regulation of apoptotic process involved in morphogenesis |
| renal vesicle morphogenesis |
| regulation of mesenchymal cell apoptotic process |
| regulation of nephron tubule epithelial cell differentiation |
| renal vesicle development |
| otic vesicle development |
| positive regulation of metanephros development |
| metanephric nephron tubule development |
| mesenchymal to epithelial transition |
| positive regulation of hormone metabolic process |
| specification of animal organ identity |
| negative regulation of kidney development |
| metanephric nephron epithelium development |
| nephron tubule formation |
| cell differentiation involved in metanephros development |
| cellular response to gonadotropin stimulus |
| metanephric tubule development |
| positive regulation of branching involved in ureteric bud morphogenesis |
| regulation of epithelial cell differentiation involved in kidney development |
| metanephric nephron morphogenesis |
| positive regulation of mesonephros development |
| metanephric epithelium development |
| thyroid gland development |
| negative regulation of cardiac muscle cell apoptotic process |
| regulation of branching involved in ureteric bud morphogenesis |
| regulation of metanephros development |
| negative regulation of striated muscle cell apoptotic process |
| regulation of mesonephros development |
| metanephros morphogenesis |
| regulation of stem cell population maintenance |
| response to gonadotropin |
| epithelial cell differentiation involved in kidney development |
| metanephric nephron development |
| negative regulation of animal organ morphogenesis |
| positive regulation of morphogenesis of an epithelium |
| animal organ formation |
| negative regulation of muscle cell apoptotic process |
| regulation of cardiac muscle cell apoptotic process |
| regulation of hormone metabolic process |
| regulation of striated muscle cell apoptotic process |
| positive regulation of kidney development |
| cell differentiation involved in kidney development |
| branching involved in ureteric bud morphogenesis |
| ureteric bud morphogenesis |
| mesonephric tubule morphogenesis |
| regulation of kidney development |
| regulation of morphogenesis of a branching structure |
| positive regulation of epithelial cell differentiation |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| regulation of muscle cell apoptotic process |
| renal tubule morphogenesis |
| ventricular septum development |
| nephron tubule development |
| renal tubule development |
| positive regulation of animal organ morphogenesis |
| metanephros development |
| kidney morphogenesis |
| ureteric bud development |
| mesonephric tubule development |
| mesonephric epithelium development |
| mesonephros development |
| nephron epithelium development |
| inner ear morphogenesis |
| cardiac septum development |
| ear morphogenesis |
| endocrine system development |
| embryonic epithelial tube formation |
| nephron development |
| cardiac ventricle development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| epithelial tube formation |
| regulation of epithelial cell differentiation |
| morphogenesis of embryonic epithelium |
| tube formation |
| morphogenesis of a branching epithelium |
| morphogenesis of a branching structure |
| cardiac chamber development |
| regulation of morphogenesis of an epithelium |
| inner ear development |
| regulation of peptide hormone secretion |
| transcription regulatory region DNA binding |
| ear development |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| regulation of hormone secretion |
| kidney development |
| renal system development |
| embryonic organ morphogenesis |
| epithelial tube morphogenesis |
| urogenital system development |
| regionalization |
| sulfur compound metabolic process |
| gland development |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| regulation of peptide secretion |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| heart development |
| regulation of hormone levels |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| cellular response to hormone stimulus |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| tube morphogenesis |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| regulation of peptide transport |
| regulation of secretion by cell |
| regulation of secretion |
| tube development |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| central nervous system development |
| negative regulation of cell death |
| regulation of anatomical structure morphogenesis |
| nucleobase-containing compound biosynthetic process |
| epithelium development |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| DNA binding |
| response to endogenous stimulus |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| HMS-I1 1μM R01 exp46 | 2.26 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.453 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 27/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 8/21 |
| liver | 1/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 8/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 9895
- Expression level (log2 read counts): 2.36
Expression Distribution
PAX8 Expression in NALM6 Cells: 2.36
