PCCA

Gene Information
  • Official Symbol: PCCA
  • Official Name: propionyl-CoA carboxylase subunit alpha
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 5095
  • UniProt: P05165
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].
  • UniProt Summary: N/A

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 6327
  • Expression level (log2 read counts): 3.42

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1