PFDN5

Entrez Summary: This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC. {ECO:0000269|PubMed:9630229}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 54/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	0/28
bone	0/25
breast	3/33
central nervous system	10/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	3/15
kidney	0/21
liver	2/20
lung	4/75
lymphocyte	1/14
ovary	1/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	1/24
soft tissue	0/7
thyroid	1/2
upper aerodigestive	6/22
urinary tract	4/29
uterus	0/5

Expression Distribution

prefoldin complex
unfolded protein binding
retina development in camera-type eye
negative regulation of canonical Wnt signaling pathway
negative regulation of Wnt signaling pathway
protein folding
transcription corepressor activity
regulation of canonical Wnt signaling pathway
camera-type eye development
eye development
regulation of Wnt signaling pathway
visual system development
sensory system development
sensory organ development
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of signal transduction
negative regulation of RNA metabolic process
negative regulation of cell communication
negative regulation of signaling
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
negative regulation of response to stimulus
negative regulation of gene expression