PIK3C2B

Official Symbol: PIK3C2B
Official Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta
Aliases and Previous Symbols: N/A
Entrez ID: 5287
UniProt: O00750
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Phosphorylates PtdIns and PtdIns4P with a preference for PtdIns. Does not phosphorylate PtdIns(4,5)P2. May be involved in EGF and PDGF signaling cascades. {ECO:0000269|PubMed:10805725}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lipid kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
1-phosphatidylinositol-3-kinase activity
phosphatidylinositol-3-phosphate biosynthetic process
phosphatidylinositol 3-kinase complex
phosphatidylinositol 3-kinase signaling
protein kinase B signaling
phosphatidylinositol phosphorylation
endocytic vesicle
autophagosome organization
lipid phosphorylation
phosphatidylinositol-mediated signaling
inositol lipid-mediated signaling
phosphatidylinositol binding
phosphatidylinositol biosynthetic process
vacuole organization
cellular response to starvation
macroautophagy
phosphatidylinositol metabolic process
response to starvation
lipid modification
glycerophospholipid biosynthetic process
glycerolipid biosynthetic process
cellular response to nutrient levels
phospholipid biosynthetic process
process utilizing autophagic mechanism
autophagy
cellular response to extracellular stimulus
glycerophospholipid metabolic process
cellular response to external stimulus
phospholipid metabolic process
glycerolipid metabolic process
response to nutrient levels
response to extracellular stimulus
organophosphate biosynthetic process
lipid biosynthetic process
organophosphate metabolic process
cellular lipid metabolic process
cell migration
endoplasmic reticulum