PLA2G2D
Gene Information
- Official Symbol: PLA2G2D
- Official Name: phospholipase A2 group IID
- Aliases and Previous Symbols: N/A
- Entrez ID: 26279
- UniProt: Q9UNK4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
Pfam Domains GO Terms
Pfam Domains
| Phospholip A2 1 |
GO Terms
| CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation |
| regulatory T cell differentiation |
| heparan sulfate proteoglycan binding |
| calcium-dependent phospholipase A2 activity |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylglycerol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| arachidonic acid secretion |
| arachidonate transport |
| phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) |
| phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylcholine acyl-chain remodeling |
| icosanoid secretion |
| phospholipase A2 activity |
| phosphatidylglycerol metabolic process |
| icosanoid transport |
| phosphatidylserine metabolic process |
| fatty acid derivative transport |
| CD4-positive, alpha-beta T cell differentiation |
| CD4-positive, alpha-beta T cell activation |
| phosphatidic acid biosynthetic process |
| phosphatidic acid metabolic process |
| alpha-beta T cell differentiation |
| long-chain fatty acid transport |
| negative regulation of T cell proliferation |
| alpha-beta T cell activation |
| fatty acid transport |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| phosphatidylcholine metabolic process |
| negative regulation of leukocyte proliferation |
| acid secretion |
| phospholipid binding |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| T cell differentiation |
| monocarboxylic acid transport |
| negative regulation of lymphocyte activation |
| regulation of T cell proliferation |
| phosphatidylinositol metabolic process |
| heparin binding |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| ammonium ion metabolic process |
| negative regulation of cell activation |
| cellular modified amino acid metabolic process |
| glycerophospholipid biosynthetic process |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| glycerolipid biosynthetic process |
| regulation of leukocyte proliferation |
| T cell activation |
| lymphocyte differentiation |
| phospholipid biosynthetic process |
| negative regulation of cell adhesion |
| carboxylic acid transport |
| organic acid transport |
| regulation of leukocyte cell-cell adhesion |
| lipid transport |
| lipid catabolic process |
| glycerophospholipid metabolic process |
| regulation of T cell activation |
| lipid localization |
| leukocyte differentiation |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| negative regulation of immune system process |
| organic anion transport |
| inflammatory response |
| regulation of lymphocyte activation |
| organophosphate biosynthetic process |
| hemopoiesis |
| lipid biosynthetic process |
| anion transport |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| regulation of cell activation |
| immune system development |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| calcium ion binding |
| organophosphate metabolic process |
| leukocyte activation |
| cellular lipid metabolic process |
| cell activation |
| secretion |
| lipid metabolic process |
| defense response |
| ion transport |
| regulation of cell population proliferation |
| regulation of immune system process |
| organic substance catabolic process |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ABT-702 5μM R07 exp318 | 1.74 |
| Nifuroxazide 1μM R01 exp51 | 1.8 |
| Q15 2.7μM R02 exp79 | 1.86 |
| NFN1 0.1μM R01 exp49 | 1.97 |
| 2-Methoxyestradiol 0.2μM R01 exp40 | 2.03 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8720
- Expression level (log2 read counts): 2.24
Expression Distribution
PLA2G2D Expression in NALM6 Cells: 2.24
