PLA2G4E

Entrez Summary: This gene encodes a member of the cytosolic phospholipase A2 group IV family. Members of this family are involved in regulation of membrane tubule-mediated transport. The enzyme encoded by this member of the family plays a role in trafficking through the clathrin-independent endocytic pathway. The enzyme regulates the recycling process via formation of tubules that transport internalized clathrin-independent cargo proteins back to the cell surface. [provided by RefSeq, Jan 2017].
UniProt Summary: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
IWR1 50μM R08 exp495	-2.14
GSK343 3μM R03 exp124	-1.97
Alpha-Amanitin 0.5μM R00 exp5	-1.85
Dimethyl-Sulfoxide 1pc R03 exp120	-1.76
Wiskostatin 3μM R07 exp422	-1.71
ONC212 0.15μM R08 exp513	1.7
FK-506 5μM R07 exp358	1.83
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.35

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

PLA2 B
C2

calcium-dependent phospholipase A2 activity
phosphatidylinositol acyl-chain remodeling
glycerophospholipid catabolic process
phosphatidylserine acyl-chain remodeling
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
phosphatidylethanolamine acyl-chain remodeling
phosphatidylcholine acyl-chain remodeling
phospholipase A2 activity
phosphatidylserine metabolic process
phospholipid catabolic process
glycerolipid catabolic process
calcium-dependent phospholipid binding
phosphatidylcholine metabolic process
organophosphate catabolic process
phosphatidylinositol metabolic process
ammonium ion metabolic process
cellular lipid catabolic process
cellular modified amino acid metabolic process
lipid catabolic process
lysosomal membrane
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
calcium ion binding
organophosphate metabolic process
cellular lipid metabolic process
lipid metabolic process
organic substance catabolic process
cellular catabolic process