PPP1CA

Gene Information

Official Symbol: PPP1CA
Official Name: protein phosphatase 1 catalytic subunit alpha
Aliases and Previous Symbols: N/A
Entrez ID: 5499
UniProt: P62136
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5- ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). {ECO:0000269|PubMed:17283141, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:25556658, ECO:0000269|PubMed:26083323}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LB-100 2μM R05 exp210	-2.55
Dihydrosphingosine 8μM R08 exp476	-2.09
Arsenate 40μM R06 exp264	-1.97
CR131-b 0.005μM R08 exp474	-1.96
Mitomycin-C 0.06μM R08 exp503	-1.89
Apcin 50 to 100μM on day4 R04 exp176	-1.83
Vemurafenib 6.6μM R08 exp434	-1.73
BVD-523 15μM R02 exp67	1.7
UM131593 0.2μM R03 exp106	1.98
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	2.25
Mdivi-1 15μM R05 exp217	2.6
UMK57 1μM R01 exp59	2.6
RO-3307 4.7μM R02 exp80	2.88
Colchicine 0.009μM R05 exp215	2.92

Global Fraction of Cell Lines Where Essential: 39/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	0/28
bone	1/25
breast	2/33
central nervous system	5/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	2/15
kidney	2/21
liver	2/20
lung	2/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	2/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	5/22
urinary tract	3/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9317
Expression level (log2 read counts): 7.21

Expression Distribution

Gene	Correlation
PPP1CC	0.558
PPP1R2	0.469
ATAT1	0.421

regulation of translational initiation by eIF2 alpha dephosphorylation
regulation of glycogen catabolic process
PTW/PP1 phosphatase complex
glycogen granule
protein phosphatase type 1 complex
regulation of cellular carbohydrate catabolic process
regulation of translational initiation in response to stress
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
peptidyl-serine dephosphorylation
peptidyl-threonine dephosphorylation
regulation of translation in response to stress
cadherin binding involved in cell-cell adhesion
protein phosphatase 1 binding
entrainment of circadian clock by photoperiod
beta-catenin destruction complex disassembly
response to lead ion
photoperiodism
entrainment of circadian clock
regulation of glucan biosynthetic process
regulation of glycogen biosynthetic process
ribonucleoprotein complex binding
regulation of glycogen metabolic process
regulation of polysaccharide biosynthetic process
phosphoprotein phosphatase activity
regulation of polysaccharide metabolic process
regulation of extrinsic apoptotic signaling pathway in absence of ligand
phosphatase activity
glycogen metabolic process
positive regulation of extrinsic apoptotic signaling pathway
cellular glucan metabolic process
glucan metabolic process
circadian regulation of gene expression
energy reserve metabolic process
protein serine/threonine phosphatase activity
cellular polysaccharide metabolic process
regulation of translational initiation
polysaccharide metabolic process
regulation of carbohydrate catabolic process
canonical Wnt signaling pathway
regulation of carbohydrate biosynthetic process