PTGES3

Entrez Summary: N/A
UniProt Summary: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Radicicol 0.16μM R05 exp242	-2.17
Trimetrexate 0.03μM R08 exp535	-1.88
UM0129480 7μM R02 exp85	1.75
MS023 7μM R03 exp135	1.83
iCRT14 30μM R08 exp492	1.88
Bisphenol A 100μM R06 exp269	2.13
Dexamethasone 0.006μM R07 exp351	2.84
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	4.73

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

prostaglandin-E synthase activity
telomerase holoenzyme complex assembly
telomerase activity
chaperone complex
cyclooxygenase pathway
chaperone-mediated protein complex assembly
prostaglandin biosynthetic process
prostanoid biosynthetic process
DNA polymerase binding
telomerase holoenzyme complex
telomere maintenance via telomerase
telomere maintenance via telomere lengthening
chaperone cofactor-dependent protein refolding
prostaglandin metabolic process
prostanoid metabolic process
RNA-dependent DNA biosynthetic process
positive regulation of telomerase activity
de novo posttranslational protein folding
de novo protein folding
Hsp90 protein binding
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
chromosome, telomeric region
regulation of telomerase activity
arachidonic acid metabolic process
chaperone-mediated protein folding
positive regulation of DNA biosynthetic process
regulation of cellular response to heat
fatty acid derivative biosynthetic process
telomere maintenance
telomere organization
chaperone binding
unsaturated fatty acid metabolic process
DNA biosynthetic process
icosanoid metabolic process
regulation of DNA biosynthetic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
xenobiotic metabolic process
unfolded protein binding