RGS19

Entrez Summary: N/A
UniProt Summary: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a » G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.8
35°C R06 exp302	1.71
Dexamethasone 0.006μM R07 exp351	1.71
LLY-283 2.6μM R06 exp290	1.9
Beta-Estradiol 0.55μM R07 exp425	2.01
CHIR-124 0.04μM R06 exp272	2.14
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

G-protein alpha-subunit binding
brush border
clathrin-coated vesicle
response to ethanol
membrane raft
response to alcohol
process utilizing autophagic mechanism
autophagy
response to antibiotic
small GTPase mediated signal transduction
GTPase activity
response to toxic substance
Golgi apparatus
response to drug
negative regulation of signal transduction
G protein-coupled receptor signaling pathway
negative regulation of cell communication
negative regulation of signaling
response to oxygen-containing compound
negative regulation of response to stimulus
intracellular signal transduction
cellular catabolic process
membrane