ROPN1L

Entrez Summary: N/A
UniProt Summary: Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation. {ECO:0000250|UniProtKB:Q9EQ00}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
HGC6.3	0.433
RRM1	0.402

epithelial cilium movement involved in extracellular fluid movement
sperm capacitation
extracellular transport
cilium movement
sperm motility
flagellated sperm motility
cilium or flagellum-dependent cell motility
cilium-dependent cell motility
motile cilium
spermatid development
spermatid differentiation
cell maturation
microtubule-based transport
cilium
developmental maturation
germ cell development
microtubule-based movement
cellular process involved in reproduction in multicellular organism
spermatogenesis
male gamete generation
developmental process involved in reproduction
microtubule-based process
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
localization of cell
cell motility
locomotion
reproductive process
reproduction
regulation of protein phosphorylation
movement of cell or subcellular component
regulation of phosphorylation
cell development
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
extracellular region