S100A1

Gene Information

Official Symbol: S100A1
Official Name: S100 calcium binding protein A1
Aliases and Previous Symbols: N/A
Entrez ID: 6271
UniProt: P23297
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Probably acts as a Ca(2+) signal transducer (PubMed:22399290). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers a conformational change (PubMed:23351007). This conformational change allows interaction of S1001A with specific target proteins, such as TPR- containing proteins, and the modulation of their activity (PubMed:22399290). {ECO:0000269|PubMed:22399290, ECO:0000269|PubMed:23351007}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15672
Expression level (log2 read counts): 1.43

Expression Distribution

Screen	Score
Cincreasin 100μM R08 exp473	-1.73
PFI-3 10μM R03 exp144	1.76
Dorsomorphin 5μM R07 exp357	2.1
Thimerosal 0.85μM R08 exp529	2.26

efhand
S 100

positive regulation of voltage-gated calcium channel activity
S100 protein binding
positive regulation of nitric-oxide synthase activity
positive regulation of monooxygenase activity
M band
regulation of voltage-gated calcium channel activity
positive regulation of calcium ion transmembrane transporter activity
positive regulation of sprouting angiogenesis
substantia nigra development
sarcoplasmic reticulum
regulation of nitric-oxide synthase activity
positive regulation of oxidoreductase activity
regulation of monooxygenase activity
calcium-dependent protein binding
neural nucleus development
positive regulation of cation channel activity
regulation of sprouting angiogenesis
positive regulation of calcium ion transmembrane transport
ATPase binding
midbrain development
regulation of calcium ion transmembrane transporter activity
regulation of oxidoreductase activity
toll-like receptor signaling pathway
positive regulation of ion transmembrane transporter activity
positive regulation of transporter activity
positive regulation of calcium ion transport
pattern recognition receptor signaling pathway
Z disc
positive regulation of cation transmembrane transport
regulation of calcium ion transmembrane transport
positive regulation of ion transmembrane transport
positive regulation of angiogenesis
regulation of cation channel activity
positive regulation of vasculature development
positive regulation of transmembrane transport
innate immune response-activating signal transduction
regulation of heart contraction
regulation of calcium ion transport
activation of innate immune response
regulation of ion transmembrane transporter activity