SAR1A

Entrez Summary: N/A
UniProt Summary: Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). {ECO:0000250, ECO:0000269|PubMed:17005010}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Gene	Correlation
SEC23B	0.561
SEC31A	0.553

regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
regulation of COPII vesicle coating
regulation of vesicle targeting, to, from or within Golgi
COPII-coated vesicle cargo loading
positive regulation of protein exit from endoplasmic reticulum
COPII vesicle coat
regulation of ER to Golgi vesicle-mediated transport
vesicle cargo loading
regulation of protein exit from endoplasmic reticulum
endoplasmic reticulum exit site
COPII-coated vesicle budding
Golgi vesicle budding
localization within membrane
vesicle budding from membrane
positive regulation of intracellular protein transport
positive regulation of intracellular transport
endoplasmic reticulum to Golgi vesicle-mediated transport
regulation of intracellular protein transport
vesicle organization
positive regulation of cellular protein localization
GTPase activity
regulation of intracellular transport
Golgi vesicle transport
GTP binding
positive regulation of protein transport
regulation of protein complex assembly
positive regulation of establishment of protein localization
regulation of cellular protein localization
regulation of vesicle-mediated transport
Golgi membrane
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
membrane organization
regulation of cellular localization
regulation of cellular component biogenesis
positive regulation of transport
intracellular protein transport
endoplasmic reticulum
regulation of protein localization