SLC12A2

Entrez Summary: The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
UniProt Summary: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
NFN1 1μM R03 exp100	-2.3
UNC2400 2μM R03 exp156	-2.1
proTAME 5μM R04 exp187	-1.72
Bortezomib 0.005μM R00 exp6	1.74
42°C R08 exp539	1.76
Ammonium tetrathiomolybdate 10μM R08 exp448	1.82
Etoposide 0.1μM R05 exp198	2
BI-6727 0.0125μM R03 exp97	2.14
I-BRD9 4μM R07 exp365	2.17
CB-5083 0.4μM R08 exp468	2.18
Milciclib 2μM R08 exp502	2.22
LY2090314 0.003μM R08 exp500 no dilution day6	2.91
LY2090314 0.003μM R08 exp499	3.1
MLN-4924 0.2μM R00 exp21	5.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AA permease
AA permease N

positive regulation of cell volume
sodium:chloride symporter activity
sodium:potassium:chloride symporter activity
transepithelial ammonium transport
transepithelial chloride transport
sodium ion transmembrane transporter activity
ammonium transmembrane transporter activity
potassium:chloride symporter activity
T cell chemotaxis
chloride ion homeostasis
ammonium transmembrane transport
transepithelial transport
hyperosmotic response
gamma-aminobutyric acid signaling pathway
monovalent inorganic anion homeostasis
cell volume homeostasis
T cell migration
potassium ion homeostasis
sodium ion homeostasis
potassium ion import across plasma membrane
lymphocyte chemotaxis
ammonium transport
extracellular vesicle
anion homeostasis
lymphocyte migration
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
response to osmotic stress
chloride transmembrane transport
response to chemokine
cellular response to chemokine
sodium ion transmembrane transport
import across plasma membrane
chloride transport
inorganic anion transmembrane transport
monovalent inorganic cation homeostasis
leukocyte chemotaxis
sodium ion transport
inorganic anion transport
potassium ion transmembrane transport