SLC9A3R1
Gene Information
- Official Symbol: SLC9A3R1
- Official Name: SLC9A3 regulator 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 9368
- UniProt: O14745
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009].
- UniProt Summary: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa. {ECO:0000250, ECO:0000269|PubMed:10499588, ECO:0000269|PubMed:18784102, ECO:0000269|PubMed:9096337, ECO:0000269|PubMed:9430655}.
Pfam Domains GO Terms
Pfam Domains
| EBP50 C-term |
| PDZ |
GO Terms
| renal phosphate ion absorption |
| dopamine receptor binding |
| negative regulation of sodium:proton antiporter activity |
| glutathione transport |
| tripeptide transport |
| growth factor receptor binding |
| beta-2 adrenergic receptor binding |
| bile acid secretion |
| renal sodium ion transport |
| regulation of sodium:proton antiporter activity |
| phospholipase C-activating dopamine receptor signaling pathway |
| chloride channel regulator activity |
| cellular divalent inorganic anion homeostasis |
| establishment of Golgi localization |
| cellular phosphate ion homeostasis |
| cellular trivalent inorganic anion homeostasis |
| oligopeptide transport |
| adenylate cyclase-activating dopamine receptor signaling pathway |
| myosin II binding |
| auditory receptor cell stereocilium organization |
| trivalent inorganic anion homeostasis |
| cellular monovalent inorganic anion homeostasis |
| divalent inorganic anion homeostasis |
| negative regulation of sodium ion transmembrane transporter activity |
| cellular anion homeostasis |
| phosphate ion homeostasis |
| negative regulation of platelet-derived growth factor receptor signaling pathway |
| negative regulation of sodium ion transmembrane transport |
| auditory receptor cell morphogenesis |
| negative regulation of phosphatidylinositol 3-kinase signaling |
| Golgi localization |
| renal absorption |
| establishment of epithelial cell apical/basal polarity |
| microvillus assembly |
| stereocilium tip |
| negative regulation of sodium ion transport |
| auditory receptor cell development |
| polarized epithelial cell differentiation |
| microvillus organization |
| establishment of apical/basal cell polarity |
| sperm midpiece |
| establishment of monopolar cell polarity |
| regulation of proton transport |
| establishment or maintenance of monopolar cell polarity |
| nuclear migration |
| microvillus membrane |
| regulation of platelet-derived growth factor receptor signaling pathway |
| regulation of excretion |
| modified amino acid transport |
| monovalent inorganic anion homeostasis |
| inner ear auditory receptor cell differentiation |
| nucleus localization |
| inner ear receptor cell stereocilium organization |
| establishment of epithelial cell polarity |
| hair cell differentiation |
| dopamine receptor signaling pathway |
| cell periphery |
| inner ear receptor cell development |
| morphogenesis of a polarized epithelium |
| neuroepithelial cell differentiation |
| sulfur compound transport |
| establishment or maintenance of epithelial cell apical/basal polarity |
| negative regulation of protein kinase B signaling |
| cofactor transport |
| molecular adaptor activity |
| columnar/cuboidal epithelial cell development |
| phosphatase binding |
| establishment or maintenance of apical/basal cell polarity |
| establishment or maintenance of bipolar cell polarity |
| inner ear receptor cell differentiation |
| regulation of sodium ion transmembrane transporter activity |
| brush border membrane |
| protein self-association |
| mechanoreceptor differentiation |
| anion homeostasis |
| positive regulation of intrinsic apoptotic signaling pathway |
| regulation of sodium ion transmembrane transport |
| microvillus |
| negative regulation of ERK1 and ERK2 cascade |
| negative regulation of ion transmembrane transporter activity |
| filopodium |
| endomembrane system |
| negative regulation of transporter activity |
| acid secretion |
| negative regulation of cation transmembrane transport |
| beta-catenin binding |
| cellular response to dopamine |
| regulation of sodium ion transport |
| response to dopamine |
| PDZ domain binding |
| signal transduction involved in cellular response to ammonium ion |
| ruffle |
| negative regulation of ion transmembrane transport |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| columnar/cuboidal epithelial cell differentiation |
| inner ear morphogenesis |
| gland morphogenesis |
| cellular response to monoamine stimulus |
| cellular response to catecholamine stimulus |
| response to monoamine |
| response to catecholamine |
| protein N-terminus binding |
| renal system process |
| negative regulation of transmembrane transport |
| ear morphogenesis |
| establishment of cell polarity |
| regulation of phosphatidylinositol 3-kinase signaling |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| cellular response to ammonium ion |
| monocarboxylic acid transport |
| vesicle |
| sensory perception of sound |
| cAMP-mediated signaling |
| negative regulation of ion transport |
| regulation of cell shape |
| sodium ion transport |
| positive regulation of ion transmembrane transport |
| regulation of intrinsic apoptotic signaling pathway |
| sensory perception of mechanical stimulus |
| negative regulation of MAPK cascade |
| cyclic-nucleotide-mediated signaling |
| negative regulation of canonical Wnt signaling pathway |
| positive regulation of apoptotic signaling pathway |
| regulation of cell size |
| protein localization to plasma membrane |
| response to ammonium ion |
| epithelial cell development |
| inner ear development |
| establishment or maintenance of cell polarity |
| positive regulation of transmembrane transport |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| negative regulation of Wnt signaling pathway |
| actin cytoskeleton |
| regulation of protein kinase B signaling |
| ear development |
| membrane raft |
| protein localization to cell periphery |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| sensory organ morphogenesis |
| regulation of ion transmembrane transporter activity |
| negative regulation of cell migration |
| regulation of transmembrane transporter activity |
| protein-containing complex binding |
| negative regulation of cell motility |
| positive regulation of ion transport |
| regulation of transporter activity |
| regulation of canonical Wnt signaling pathway |
| embryonic organ morphogenesis |
| organic acid transport |
| carboxylic acid transport |
| regulation of ERK1 and ERK2 cascade |
| negative regulation of mitotic cell cycle |
| negative regulation of cellular component movement |
| epidermal cell differentiation |
| apical plasma membrane |
| negative regulation of locomotion |
| regulation of cation transmembrane transport |
| signaling receptor binding |
| second-messenger-mediated signaling |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| establishment of organelle localization |
| regulation of cellular component size |
| regulation of metal ion transport |
| regulation of apoptotic signaling pathway |
| monovalent inorganic cation transport |
| cellular response to drug |
| negative regulation of protein phosphorylation |
| gland development |
| epidermis development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| morphogenesis of an epithelium |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| negative regulation of phosphorylation |
| plasma membrane bounded cell projection assembly |
| cell projection assembly |
| organic anion transport |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| negative regulation of transport |
| regulation of cell morphogenesis |
| actin cytoskeleton organization |
| negative regulation of intracellular signal transduction |
| regulation of anatomical structure size |
| cellular response to organic cyclic compound |
| sensory organ development |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| regulation of transmembrane transport |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| negative regulation of cell cycle |
| organelle localization |
| anion transport |
| regulation of system process |
| negative regulation of protein modification process |
| cellular response to organonitrogen compound |
| regulation of mitotic cell cycle |
| metal ion transport |
| positive regulation of apoptotic process |
| cellular ion homeostasis |
| positive regulation of programmed cell death |
| cellular response to nitrogen compound |
| neuron projection development |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| regulation of ion transport |
| inorganic ion homeostasis |
| cell morphogenesis |
| cellular chemical homeostasis |
| regulation of MAPK cascade |
| ion homeostasis |
| regulation of protein kinase activity |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| cation transport |
| regulation of cell migration |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of cell motility |
| response to organic cyclic compound |
| animal organ morphogenesis |
| sensory perception |
| regulation of transferase activity |
| embryo development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| response to organonitrogen compound |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| response to drug |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| response to nitrogen compound |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| chemical homeostasis |
| epithelium development |
| cell-cell signaling |
| secretion |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| regulation of cell cycle |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| ion transport |
| nervous system process |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| intracellular transport |
| generation of neurons |
| peptide transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| protein-containing complex subunit organization |
| regulation of transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Torin1 0.08μM R02 exp82 | -2.06 |
| Lead acetate 2000μM R08 exp497 | -1.91 |
| LJH685 5μM R02 exp73 | 1.71 |
| UM0130462 0.025 to 0.035μM day4 R05 exp247 | 1.72 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9488
- Expression level (log2 read counts): 3.24
Expression Distribution
SLC9A3R1 Expression in NALM6 Cells: 3.24
