SNX9

Entrez Summary: N/A
UniProt Summary: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate. {ECO:0000269|PubMed:11799118, ECO:0000269|PubMed:12952949, ECO:0000269|PubMed:15703209, ECO:0000269|PubMed:17609109, ECO:0000269|PubMed:17948057, ECO:0000269|PubMed:18388313, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

lipid tube assembly
cleavage furrow formation
cuticular plate
Arp2/3 complex binding
positive regulation of membrane protein ectodomain proteolysis
1-phosphatidylinositol binding
plasma membrane tubulation
regulation of membrane protein ectodomain proteolysis
positive regulation of protein oligomerization
protein-lipid complex assembly
cytokinetic process
regulation of protein oligomerization
protein-lipid complex subunit organization
clathrin-coated vesicle
extrinsic component of cytoplasmic side of plasma membrane
mitotic cytokinesis
phosphatidylinositol binding
positive regulation of actin filament polymerization
plasma membrane organization
ruffle
cytoskeleton-dependent cytokinesis
cytokinesis
positive regulation of protein polymerization
plasma membrane invagination
cytoplasmic vesicle membrane
membrane invagination
regulation of actin filament polymerization
trans-Golgi network
regulation of actin polymerization or depolymerization
regulation of actin filament length
positive regulation of supramolecular fiber organization
positive regulation of protein catabolic process
positive regulation of cytoskeleton organization
regulation of protein polymerization
endosomal transport
receptor-mediated endocytosis
positive regulation of protein complex assembly
cytoplasmic vesicle
regulation of actin filament organization
ubiquitin protein ligase binding