SOX10

Entrez Summary: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008].
UniProt Summary: Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). {ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:21965087}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 41/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	16/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Sox N
HMG box

extrinsic component of mitochondrial outer membrane
cellular response to progesterone stimulus
regulation of Schwann cell proliferation
negative regulation of Schwann cell proliferation
lacrimal gland development
enteric nervous system development
negative regulation of glial cell proliferation
positive regulation of myelination
central nervous system myelination
axon ensheathment in central nervous system
melanocyte differentiation
positive regulation of neuroblast proliferation
regulation of glial cell proliferation
pigment cell differentiation
regulation of neuroblast proliferation
positive regulation of stem cell proliferation
developmental pigmentation
negative regulation of gliogenesis
oligodendrocyte development
regulation of myelination
exocrine system development
response to progesterone
autonomic nervous system development
digestive tract morphogenesis
promoter-specific chromatin binding
positive regulation of neural precursor cell proliferation
neural crest cell migration
positive regulation of nervous system process
regulation of stem cell proliferation
oligodendrocyte differentiation
positive regulation of gliogenesis
peripheral nervous system development
transcription elongation from RNA polymerase II promoter
neural crest cell development
mesenchymal cell development
stem cell development
regulation of neural precursor cell proliferation
neural crest cell differentiation
DNA-templated transcription, elongation
cellular response to ketone