TAB3

Gene Information

Official Symbol: TAB3
Official Name: TGF-beta activated kinase 1 (MAP3K7) binding protein 3
Aliases and Previous Symbols: N/A
Entrez ID: 257397
UniProt: Q8N5C8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor. {ECO:0000269|PubMed:14633987, ECO:0000269|PubMed:14766965}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17209
Expression level (log2 read counts): 5.46

Expression Distribution

Screen	Score
S-trityl-L-cysteine 0.5μM R05 exp243	-1.81
Benzoate 20000μM R08 exp456	-1.76
QNZ 0.01μM R08 exp439	1.71
Beta-Estradiol 0.55μM R07 exp425	2.24

nucleotide-binding oligomerization domain containing signaling pathway
nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
MyD88-dependent toll-like receptor signaling pathway
cytoplasmic pattern recognition receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
JNK cascade
negative regulation of autophagy
interleukin-1-mediated signaling pathway
toll-like receptor signaling pathway
stress-activated MAPK cascade
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
pattern recognition receptor signaling pathway
stress-activated protein kinase signaling cascade
positive regulation of NF-kappaB transcription factor activity
activation of MAPK activity
intracellular receptor signaling pathway
Fc-epsilon receptor signaling pathway
cellular response to interleukin-1
positive regulation of I-kappaB kinase/NF-kappaB signaling
response to interleukin-1
endosome membrane
innate immune response-activating signal transduction
regulation of I-kappaB kinase/NF-kappaB signaling
Fc receptor signaling pathway
negative regulation of cellular catabolic process
activation of innate immune response
positive regulation of DNA-binding transcription factor activity
positive regulation of MAP kinase activity
negative regulation of catabolic process
activation of protein kinase activity
regulation of autophagy
positive regulation of protein serine/threonine kinase activity
positive regulation of innate immune response
regulation of MAP kinase activity
positive regulation of response to biotic stimulus
MAPK cascade
signal transduction by protein phosphorylation
regulation of DNA-binding transcription factor activity
immune response-activating cell surface receptor signaling pathway