TCAF2

Gene Information

Official Symbol: TCAF2
Official Name: TRPM8 channel associated factor 2
Aliases and Previous Symbols: N/A
Entrez ID: 285966
UniProt: A6NFQ2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Isoform 2: Negatively regulates the plasma membrane cation channel TRPM8 activity. Involved in the recruitment of TRPM8 to the cell surface. Promotes prostate cancer cell migration stimulation in a TRPM8-dependent manner. {ECO:0000269|PubMed:25559186}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
EPZ-5676 30μM R05 exp233	-2.07
Metformin 100 to 150μM on day4 R04 exp170	-2.01
AICAR 240μM R05 exp211	-1.91
Isoniazid 100μM R08 exp494	-1.89
Nicotinamide 1000μM R03 exp101	-1.88
All-trans-Retinoic-Acid 8μM R07 exp333	-1.75
Arsenic trioxide 60μM R08 exp449	1.82
HMS-I1 1μM R01 exp46	2.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 14516
Expression level (log2 read counts): 2.56

Expression Distribution

negative regulation of anion channel activity
regulation of anion channel activity
negative regulation of anion transmembrane transport
regulation of anion transmembrane transport
negative regulation of anion transport
positive regulation of protein targeting to membrane
regulation of protein targeting to membrane
negative regulation of ion transmembrane transporter activity
negative regulation of transporter activity
regulation of protein targeting
regulation of anion transport
negative regulation of ion transmembrane transport
negative regulation of transmembrane transport
positive regulation of protein localization to membrane
ion channel binding
negative regulation of ion transport
positive regulation of intracellular protein transport
regulation of protein localization to membrane
positive regulation of intracellular transport
regulation of intracellular protein transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
positive regulation of cellular protein localization
regulation of intracellular transport
positive regulation of protein transport
positive regulation of establishment of protein localization
regulation of ion transmembrane transport
negative regulation of transport
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
regulation of cellular protein localization
cell junction
positive regulation of locomotion
regulation of transmembrane transport
regulation of ion transport
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization