TENM3

Entrez Summary: This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015].
UniProt Summary: Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes axon guidance and homophilic cell adhesion. Plays a role in the development of the visual pathway; regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes. May function as a cellular signal transducer (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of homophilic cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
cell adhesion molecule binding
camera-type eye morphogenesis
eye morphogenesis
homophilic cell adhesion via plasma membrane adhesion molecules
sensory organ morphogenesis
cell-cell adhesion via plasma-membrane adhesion molecules
positive regulation of neuron projection development
axon
camera-type eye development
neuron projection
eye development
visual system development
positive regulation of neuron differentiation
sensory system development
positive regulation of cell projection organization
regulation of cell-cell adhesion
positive regulation of neurogenesis
protein heterodimerization activity
regulation of neuron projection development
cell-cell adhesion
positive regulation of nervous system development
positive regulation of cell development
sensory organ development
regulation of neuron differentiation
regulation of cell adhesion
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
neuron development
regulation of neurogenesis
protein homodimerization activity
regulation of nervous system development
cell adhesion
regulation of cell development
biological adhesion
animal organ morphogenesis
positive regulation of cell differentiation
neuron differentiation
positive regulation of cellular component organization