THY1
Gene Information
- Official Symbol: THY1
- Official Name: Thy-1 cell surface antigen
- Aliases and Previous Symbols: N/A
- Entrez ID: 7070
- UniProt: P04216
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Pfam Domains GO Terms
Pfam Domains
| ig |
GO Terms
| regulation of Rho-dependent protein serine/threonine kinase activity |
| GPI anchor binding |
| retinal cone cell differentiation |
| retinal cone cell development |
| axolemma |
| negative regulation of neuron projection regeneration |
| positive regulation of heterotypic cell-cell adhesion |
| positive regulation of cellular extravasation |
| camera-type eye photoreceptor cell differentiation |
| anchored component of external side of plasma membrane |
| negative regulation of T cell receptor signaling pathway |
| positive regulation of focal adhesion assembly |
| regulation of heterotypic cell-cell adhesion |
| cell-substrate adherens junction assembly |
| negative regulation of antigen receptor-mediated signaling pathway |
| focal adhesion assembly |
| neuronal cell body membrane |
| dendrite membrane |
| regulation of neuron projection regeneration |
| regulation of cellular extravasation |
| negative regulation of protein tyrosine kinase activity |
| positive regulation of adherens junction organization |
| positive regulation of cell junction assembly |
| eye photoreceptor cell development |
| adherens junction assembly |
| regulation of T cell receptor signaling pathway |
| positive regulation of release of sequestered calcium ion into cytosol |
| cell-substrate junction assembly |
| eye photoreceptor cell differentiation |
| photoreceptor cell development |
| receptor clustering |
| retina morphogenesis in camera-type eye |
| positive regulation of cell-matrix adhesion |
| negative regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of calcium ion transport into cytosol |
| photoreceptor cell differentiation |
| neural retina development |
| regulation of focal adhesion assembly |
| regulation of cell-substrate junction assembly |
| regulation of antigen receptor-mediated signaling pathway |
| regulation of adherens junction organization |
| negative regulation of axonogenesis |
| positive regulation of calcium ion transmembrane transport |
| regulation of release of sequestered calcium ion into cytosol |
| adherens junction organization |
| localization within membrane |
| regulation of cell junction assembly |
| regulation of protein tyrosine kinase activity |
| integrin-mediated signaling pathway |
| negative regulation of cell morphogenesis involved in differentiation |
| regulation of calcium ion transport into cytosol |
| camera-type eye morphogenesis |
| regulation of cell-matrix adhesion |
| positive regulation of calcium ion transport |
| positive regulation of cell-substrate adhesion |
| regulation of sequestering of calcium ion |
| cell-matrix adhesion |
| positive regulation of leukocyte migration |
| growth cone |
| integrin binding |
| retina development in camera-type eye |
| positive regulation of cation transmembrane transport |
| regulation of calcium ion transmembrane transport |
| eye morphogenesis |
| negative regulation of neuron projection development |
| positive regulation of ion transmembrane transport |
| cell junction assembly |
| T cell receptor signaling pathway |
| negative regulation of cell projection organization |
| cell-substrate adhesion |
| regulation of axonogenesis |
| protein autophosphorylation |
| regulation of leukocyte migration |
| positive regulation of T cell activation |
| positive regulation of transmembrane transport |
| regulation of cell-substrate adhesion |
| cell junction organization |
| positive regulation of leukocyte cell-cell adhesion |
| negative regulation of neuron differentiation |
| negative regulation of protein kinase activity |
| membrane raft |
| negative regulation of kinase activity |
| regulation of calcium ion transport |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of cell-cell adhesion |
| sensory organ morphogenesis |
| negative regulation of cell migration |
| negative regulation of cell motility |
| positive regulation of ion transport |
| negative regulation of transferase activity |
| GTPase activator activity |
| positive regulation of cytosolic calcium ion concentration |
| negative regulation of neurogenesis |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| camera-type eye development |
| regulation of T cell activation |
| angiogenesis |
| apical plasma membrane |
| negative regulation of locomotion |
| regulation of cytosolic calcium ion concentration |
| negative regulation of cell development |
| regulation of cation transmembrane transport |
| eye development |
| positive regulation of lymphocyte activation |
| visual system development |
| sensory system development |
| regulation of metal ion transport |
| external side of plasma membrane |
| regulation of cell-cell adhesion |
| positive regulation of cell adhesion |
| positive regulation of leukocyte activation |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| positive regulation of GTPase activity |
| focal adhesion |
| positive regulation of cell activation |
| dendrite |
| cellular calcium ion homeostasis |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| immune response-activating cell surface receptor signaling pathway |
| calcium ion homeostasis |
| protein kinase binding |
| cellular divalent inorganic cation homeostasis |
| regulation of ion transmembrane transport |
| protein localization to membrane |
| immune response-regulating cell surface receptor signaling pathway |
| regulation of GTPase activity |
| blood vessel development |
| regulation of cell morphogenesis |
| divalent inorganic cation homeostasis |
| regulation of neuron projection development |
| positive regulation of cell migration |
| cell-cell adhesion |
| vasculature development |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cellular component biogenesis |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| sensory organ development |
| positive regulation of locomotion |
| cellular metal ion homeostasis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| regulation of transmembrane transport |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| regulation of leukocyte activation |
| cell surface |
| metal ion homeostasis |
| activation of immune response |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| tube morphogenesis |
| regulation of neuron differentiation |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| negative regulation of cellular component organization |
| cation homeostasis |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| inorganic ion homeostasis |
| regulation of cellular response to stress |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| tube development |
| regulation of cell migration |
| positive regulation of immune response |
| circulatory system development |
| regulation of kinase activity |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| protein phosphorylation |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| endoplasmic reticulum |
| neuron differentiation |
| negative regulation of cellular protein metabolic process |
| regulation of anatomical structure morphogenesis |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| chemical homeostasis |
| cell-cell signaling |
| negative regulation of molecular function |
| regulation of immune response |
| positive regulation of immune system process |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| phosphorylation |
| negative regulation of cell communication |
| negative regulation of signaling |
| integral component of plasma membrane |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| generation of neurons |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| negative regulation of response to stimulus |
| neurogenesis |
| homeostatic process |
| cell development |
| regulation of immune system process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Clomiphene 4.4μM R02 exp68 | -2.22 |
| Quinacrine 2.5μM R03 exp146 | -2.19 |
| LB-100 4.1μM R02 exp72 | -1.95 |
| RK-33 8μM R08 exp518 | -1.95 |
| PNU96415E 10μM R03 exp145 | -1.87 |
| Nifuroxazide 5μM R03 exp102 | -1.84 |
| PF-06409577 20μM R07 exp389 | -1.82 |
| Vinblastine 0.2μM R03 exp108 | -1.78 |
| BI-6727 0.001μM R01 exp42 | 1.76 |
| Torin1 0.08μM R02 exp82 | 1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15974
- Expression level (log2 read counts): -2.79
Expression Distribution
THY1 Expression in NALM6 Cells: -2.79
