TMEM66

Entrez Summary: N/A
UniProt Summary: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. {ECO:0000269|PubMed:22464749}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wortmannin 5μM R00 exp38	-1.76
CCT251545 0.2μM R06 exp271	1.7
Actinomycin-D 0.01μM R00 exp4	1.75
All-trans-Retinoic-Acid 8μM R07 exp333	1.81
Centrinone 0.5μM R07 exp343	1.87
ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319	2.08

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

endoplasmic reticulum-plasma membrane contact site
regulation of store-operated calcium entry
integral component of endoplasmic reticulum membrane
regulation of calcium ion transport
calcium ion transport
divalent metal ion transport
divalent inorganic cation transport
regulation of metal ion transport
metal ion transport
regulation of ion transport
cation transport
endoplasmic reticulum
ion transport
regulation of transport