TMEM79

Entrez Summary: N/A
UniProt Summary: Contributes to the epidermal integrity and skin barrier function. Plays a role in the lamellar granule (LG) secretory system and in the stratum corneum (SC) epithelial cell formation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp500 no dilution day6	-1.7
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.79
BN82002 4μM R07 exp340	1.83
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	1.83
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.85
THZ531 0.11μM R07 exp409	1.9
Senexin-A 25μM R07 exp400	1.93
Rifampicin 30μM R08 exp430	2
Ribavirin 10μM R01 exp52	2.02
Cyclosporin-A 0.8μM R07 exp347	2.11
Lapatinib 5μM R01 exp47	2.14

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cuticle development
epithelial cell maturation
establishment of skin barrier
hair follicle morphogenesis
regulation of water loss via skin
epidermis morphogenesis
positive regulation of epidermis development
multicellular organismal water homeostasis
hair follicle development
skin epidermis development
water homeostasis
molting cycle process
hair cycle process
regulation of epidermis development
hair cycle
molting cycle
trans-Golgi network membrane
cornification
anatomical structure maturation
cell maturation
epithelial cell development
keratinization
developmental maturation
keratinocyte differentiation
lysosomal membrane
epidermal cell differentiation
multicellular organismal homeostasis
skin development
epidermis development
morphogenesis of an epithelium
regulation of body fluid levels
tissue morphogenesis
epithelial cell differentiation
regulated exocytosis
exocytosis
secretion by cell
export from cell
programmed cell death
identical protein binding
cell death