TSPYL5

Gene Information

Official Symbol: TSPYL5
Official Name: TSPY like 5
Aliases and Previous Symbols: N/A
Entrez ID: 85453
UniProt: Q86VY4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269|PubMed:20079711, ECO:0000269|PubMed:21170034}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 275/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	11/28
blood	17/28
bone	11/26
breast	14/33
central nervous system	16/56
cervix	3/4
colorectal	7/17
esophagus	4/13
fibroblast	0/1
gastric	7/16
kidney	8/21
liver	7/20
lung	25/75
lymphocyte	6/16
ovary	12/26
pancreas	6/24
peripheral nervous system	11/16
plasma cell	7/15
prostate	1/1
skin	5/24
soft tissue	5/9
thyroid	0/2
upper aerodigestive	6/22
urinary tract	3/29
uterus	2/5

Essentiality in NALM6

Essentiality Rank: 5384
Expression level (log2 read counts): -5.01

Expression Distribution

cellular response to gamma radiation
response to gamma radiation
cellular response to ionizing radiation
positive regulation of protein ubiquitination
nucleosome assembly
chromatin assembly
positive regulation of protein modification by small protein conjugation or removal
response to ionizing radiation
chromatin assembly or disassembly
nucleosome organization
positive regulation of protein kinase B signaling
cellular response to radiation
DNA packaging
regulation of protein ubiquitination
protein-DNA complex assembly
regulation of protein kinase B signaling
regulation of protein modification by small protein conjugation or removal
protein-DNA complex subunit organization
DNA conformation change
cellular response to abiotic stimulus
cellular response to environmental stimulus
response to radiation
regulation of growth
chromatin organization
cellular protein-containing complex assembly
positive regulation of cell population proliferation
positive regulation of intracellular signal transduction
chromosome organization
response to abiotic stimulus
positive regulation of protein modification process
protein-containing complex assembly
positive regulation of cellular protein metabolic process
regulation of cell population proliferation
positive regulation of signal transduction
positive regulation of protein metabolic process
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of protein modification process
protein-containing complex subunit organization