TTF2

Entrez Summary: N/A
UniProt Summary: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing. {ECO:0000269|PubMed:10455150, ECO:0000269|PubMed:12927788, ECO:0000269|PubMed:15125840, ECO:0000269|PubMed:9748214}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 117/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	6/28
bone	6/25
breast	3/33
central nervous system	4/56
cervix	0/4
colorectal	5/17
esophagus	3/13
fibroblast	0/1
gastric	3/15
kidney	5/21
liver	4/20
lung	17/75
lymphocyte	3/14
ovary	3/26
pancreas	4/24
peripheral nervous system	2/16
plasma cell	4/15
prostate	0/1
skin	5/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	3/22
urinary tract	6/29
uterus	1/5

Expression Distribution

Helicase C
SNF2 N

transcription elongation factor complex
termination of RNA polymerase II transcription
helicase activity
DNA-dependent ATPase activity
DNA-templated transcription, termination
spliceosomal complex
RNA splicing
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
zinc ion binding
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
DNA binding
ATP binding
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression