TXNRD3NB

Entrez Summary: N/A
UniProt Summary: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). {ECO:0000250|UniProtKB:Q99MD6}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

Screen	Score
Hydroxyurea 15μM R06 exp289	1.71
Aphidicolin 0.04μM R06 exp263	1.75

thioredoxin-disulfide reductase activity
protein disulfide oxidoreductase activity
flavin adenine dinucleotide binding
cell redox homeostasis
electron transfer activity
cellular oxidant detoxification
cellular detoxification
detoxification
electron transport chain
cellular response to toxic substance
generation of precursor metabolites and energy
response to toxic substance
spermatogenesis
male gamete generation
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
cellular homeostasis
oxidation-reduction process
multi-organism reproductive process
endoplasmic reticulum
mitochondrion
reproductive process
reproduction
homeostatic process