UBE2V2

Entrez Summary: N/A
UniProt Summary: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. {ECO:0000269|PubMed:10089880, ECO:0000269|PubMed:14562038, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:9705497}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Tunicamycin 0.04μM R07 exp418	1.75
KU-0063794 3.8μM R02 exp71	1.96
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	2.25
Tunicamycin 0.04 to 0.075μM on day4 R07 exp419	2.29
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.4

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

error-free postreplication DNA repair
UBC13-MMS2 complex
DNA double-strand break processing
protein K63-linked ubiquitination
ubiquitin conjugating enzyme activity
postreplication repair
double-strand break repair via nonhomologous end joining
non-recombinational repair
regulation of DNA repair
double-strand break repair
regulation of response to DNA damage stimulus
protein polyubiquitination
regulation of DNA metabolic process
DNA repair
protein ubiquitination
regulation of cellular response to stress
DNA metabolic process
protein modification by small protein conjugation
cellular response to DNA damage stimulus
protein modification by small protein conjugation or removal
regulation of response to stress
cellular response to stress