VLDLR

Entrez Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009].
UniProt Summary: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nifuroxazide 1μM R01 exp51	-1.82
Q15 2.7μM R02 exp79	1.89

reelin receptor activity
very-low-density lipoprotein particle binding
very-low-density lipoprotein particle receptor activity
glycoprotein transport
very-low-density lipoprotein particle clearance
reelin-mediated signaling pathway
low-density lipoprotein particle receptor catabolic process
low-density lipoprotein receptor particle metabolic process
low-density lipoprotein particle receptor activity
cargo receptor activity
apolipoprotein binding
very-low-density lipoprotein particle
receptor catabolic process
plasma lipoprotein particle clearance
ventral spinal cord development
clathrin-coated pit
dendrite morphogenesis
calcium-dependent protein binding
carbohydrate derivative transport
regulation of plasma lipoprotein particle levels
positive regulation of dendrite development
dendrite development
receptor metabolic process
spinal cord development
cholesterol metabolic process
memory
secondary alcohol metabolic process
sterol metabolic process
regulation of dendrite development
receptor complex
receptor-mediated endocytosis
learning or memory
axon guidance
steroid metabolic process
neuron projection guidance
positive regulation of neuron projection development
lipid transport
cognition
lysosomal membrane
alcohol metabolic process