VTN
Gene Information
- Official Symbol: VTN
- Official Name: vitronectin
- Aliases and Previous Symbols: N/A
- Entrez ID: 7448
- UniProt: P04004
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Pfam Domains GO Terms
Pfam Domains
| Somatomedin B |
| Hemopexin |
GO Terms
| smooth muscle cell-matrix adhesion |
| rough endoplasmic reticulum lumen |
| alphav-beta3 integrin-vitronectin complex |
| positive regulation of vascular endothelial growth factor receptor signaling pathway |
| polysaccharide binding |
| cell adhesion mediated by integrin |
| extracellular matrix binding |
| liver regeneration |
| regulation of vascular endothelial growth factor receptor signaling pathway |
| positive regulation of smooth muscle cell migration |
| endodermal cell differentiation |
| endoderm formation |
| negative regulation of blood coagulation |
| scavenger receptor activity |
| negative regulation of hemostasis |
| positive regulation of receptor-mediated endocytosis |
| negative regulation of coagulation |
| positive regulation of wound healing |
| regulation of smooth muscle cell migration |
| collagen binding |
| positive regulation of response to wounding |
| oligodendrocyte differentiation |
| negative regulation of wound healing |
| endoderm development |
| animal organ regeneration |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of coagulation |
| negative regulation of response to wounding |
| protein polymerization |
| basement membrane |
| positive regulation of protein binding |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| Golgi lumen |
| formation of primary germ layer |
| regulation of complement activation |
| positive regulation of cell-substrate adhesion |
| liver development |
| cell-matrix adhesion |
| hepaticobiliary system development |
| integrin binding |
| extracellular matrix structural constituent |
| regulation of humoral immune response |
| regulation of wound healing |
| blood microparticle |
| regeneration |
| gastrulation |
| regulation of response to wounding |
| heparin binding |
| glial cell differentiation |
| positive regulation of binding |
| cell-substrate adhesion |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of endocytosis |
| regulation of cell-substrate adhesion |
| gliogenesis |
| regulation of protein binding |
| negative regulation of endopeptidase activity |
| regulation of peptidyl-tyrosine phosphorylation |
| negative regulation of peptidase activity |
| regulation of cellular response to growth factor stimulus |
| extracellular matrix organization |
| negative regulation of proteolysis |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| regulation of binding |
| extracellular structure organization |
| positive regulation of cell adhesion |
| gland development |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| regulation of immune effector process |
| regulation of body fluid levels |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| regulation of vesicle-mediated transport |
| positive regulation of locomotion |
| cell population proliferation |
| endocytosis |
| embryonic morphogenesis |
| import into cell |
| regulation of cell adhesion |
| intracellular membrane-bounded organelle |
| regulation of proteolysis |
| negative regulation of catalytic activity |
| cellular protein-containing complex assembly |
| regulation of cell migration |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| cell adhesion |
| biological adhesion |
| cell migration |
| embryo development |
| central nervous system development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| endoplasmic reticulum |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| identical protein binding |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| locomotion |
| regulation of protein phosphorylation |
| regulation of response to stress |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Apcin 25μM plus proTAME 2μM R04 exp177 | -2.03 |
| Pterostilbene 16μM R02 exp78 | -1.8 |
| Vinblastine 0.015μM R05 exp208 | 2.23 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12506
- Expression level (log2 read counts): -2.6
Expression Distribution
VTN Expression in NALM6 Cells: -2.6
