YES1

Gene Information

Official Symbol: YES1
Official Name: YES proto-oncogene 1, Src family tyrosine kinase
Aliases and Previous Symbols: N/A
Entrez ID: 7525
UniProt: P07947
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis. {ECO:0000269|PubMed:11901164, ECO:0000269|PubMed:18479465, ECO:0000269|PubMed:19276087, ECO:0000269|PubMed:21566460, ECO:0000269|PubMed:21713032}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bisphenol S 100μM R08 exp458	-1.97
EPZ-5676 30μM R05 exp233	-1.85
SB203580 25μM R03 exp149	-1.75
Lead acetate 2000μM R08 exp497	-1.74
ZLN024 50μM R08 exp538	-1.7
Vinblastine 0.2μM R03 exp108	2.06
SNS-032 15μM R08 exp443	2.22

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18807
Expression level (log2 read counts): 4.36

Expression Distribution

SH3 2
SH2
Pkinase Tyr
SH3 1
Pkinase

postsynaptic specialization, intracellular component
cellular response to platelet-derived growth factor stimulus
response to platelet-derived growth factor
peptidyl-tyrosine autophosphorylation
epidermal growth factor receptor binding
regulation of vascular permeability
phosphotyrosine residue binding
non-membrane spanning protein tyrosine kinase activity
T cell costimulation
lymphocyte costimulation
extrinsic component of cytoplasmic side of plasma membrane
cellular response to retinoic acid
regulation of glucose transmembrane transport
actin filament
ephrin receptor signaling pathway
protein tyrosine kinase activity
response to retinoic acid
ion channel binding
Fc-gamma receptor signaling pathway involved in phagocytosis
immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
Fc receptor mediated stimulatory signaling pathway
Fc-gamma receptor signaling pathway
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
cellular response to transforming growth factor beta stimulus
microtubule organizing center
response to transforming growth factor beta
vascular process in circulatory system
positive regulation of peptidyl-tyrosine phosphorylation
protein autophosphorylation
positive regulation of T cell activation
cellular response to acid chemical
positive regulation of leukocyte cell-cell adhesion
Fc receptor signaling pathway
regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell-cell adhesion
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
phagocytosis
signaling receptor binding