GSK2606414 1μM R05 exp236
Mechanism of Action
Inhibits PERK, also KIT receptor
- Class / Subclass 1: Signal Transduction / Kinase Inhibitor
Technical Notes
Compound References
- PubChem Name: CID 53469448
- Synonyms: N/A
- CAS #: 1337531-36-8
- PubChem CID: 53469448
- IUPAC: 1-[5-(4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone
- INCHI Name: InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)
- INCHI Key: SIXVRXARNAVBTC-UHFFFAOYSA-N
- Molecular Weight: 451.4
- Canonical SMILES: CN1C=C(C2=C(N=CN=C21)N)C3=CC4=C(C=C3)N(CC4)C(=O)CC5=CC(=CC=C5)C(F)(F)F
- Isomeric SMILES: N/A
- Molecular Formula: C24H20F3N5O
Compound Supplier
- Supplier Name: N/A
- Catalog #: N/A
- Lot #: N/A
Compound Characterization
- HRMS (ESI-TOF) m/z: [M+H]+ Calcd for C21H21F3N5O 452.1693; found 452.1682
Dose Response Curve
- Platform ID: GSK2606414
- Min: -5.0193; Max: 14.8932
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 05
- Dose: 1µM
- Days of incubation: 8
- Doublings: 6.8
- Numbers of reads: 13642122
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/1 | Scores |
GSK2606414 1μM R05 exp236
