AACS
Gene Information
- Official Symbol: AACS
- Official Name: acetoacetyl-CoA synthetase
- Aliases and Previous Symbols: N/A
- Entrez ID: 65985
- UniProt: Q86V21
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| AMP-binding |
| DUF3448 |
GO Terms
| acetoacetate-CoA ligase activity |
| response to oleic acid |
| butyrate-CoA ligase activity |
| cellular response to testosterone stimulus |
| ketone body biosynthetic process |
| cellular ketone body metabolic process |
| ketone body metabolic process |
| white fat cell differentiation |
| cellular response to cholesterol |
| cellular response to sterol |
| response to cholesterol |
| response to sterol |
| adipose tissue development |
| response to testosterone |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| positive regulation of insulin secretion |
| cellular response to carbohydrate stimulus |
| response to fatty acid |
| cellular response to alcohol |
| cellular glucose homeostasis |
| fatty acid derivative biosynthetic process |
| cellular response to ketone |
| positive regulation of peptide hormone secretion |
| fat cell differentiation |
| liver development |
| response to ethanol |
| positive regulation of hormone secretion |
| hepaticobiliary system development |
| response to glucose |
| response to hexose |
| response to monosaccharide |
| response to purine-containing compound |
| fatty acid derivative metabolic process |
| response to carbohydrate |
| regulation of insulin secretion |
| glucose homeostasis |
| carbohydrate homeostasis |
| response to starvation |
| response to ketone |
| regulation of peptide hormone secretion |
| response to nutrient |
| connective tissue development |
| response to alcohol |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| response to antibiotic |
| fatty acid metabolic process |
| response to acid chemical |
| positive regulation of secretion by cell |
| gland development |
| generation of precursor metabolites and energy |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of peptide secretion |
| response to nutrient levels |
| drug metabolic process |
| response to toxic substance |
| cellular response to lipid |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| regulation of hormone levels |
| cellular response to organic cyclic compound |
| small molecule biosynthetic process |
| cellular response to hormone stimulus |
| regulation of protein transport |
| regulation of peptide transport |
| cellular chemical homeostasis |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| response to lipid |
| cellular homeostasis |
| carboxylic acid metabolic process |
| response to hormone |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| positive regulation of transport |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| regulation of protein localization |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| chemical homeostasis |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| response to endogenous stimulus |
| ATP binding |
| response to oxygen-containing compound |
| homeostatic process |
| small molecule metabolic process |
| tissue development |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0129480 7μM R02 exp85 | 1.71 |
| MKC9989 10μM R03 exp133 | 1.73 |
| Cycloheximide 0.02μM R00 exp14 | 1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5662
- Expression level (log2 read counts): 5.52
Expression Distribution
AACS Expression in NALM6 Cells: 5.52
