AANAT

Entrez Summary: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
UniProt Summary: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N- acetylserotonin, the penultimate step in the synthesis of melatonin. {ECO:0000269|PubMed:11313340, ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Phenformin 20μM R05 exp212	-1.8
A-366 10μM R03 exp115	-1.75

aralkylamine N-acetyltransferase activity
melatonin metabolic process
melatonin biosynthetic process
arylamine N-acetyltransferase activity
indole-containing compound biosynthetic process
indolalkylamine biosynthetic process
N-terminal protein amino acid acetylation
indolalkylamine metabolic process
response to corticosterone
cellular biogenic amine biosynthetic process
response to prostaglandin E
amine biosynthetic process
indole-containing compound metabolic process
photoperiodism
N-terminal protein amino acid modification
14-3-3 protein binding
response to prostaglandin
response to mineralocorticoid
response to copper ion
cellular response to cAMP
response to zinc ion
cellular biogenic amine metabolic process
cellular amine metabolic process
hormone biosynthetic process
amine metabolic process
response to fatty acid
response to cAMP
cellular hormone metabolic process
response to organophosphorus
circadian rhythm
protein acetylation
response to glucocorticoid
response to calcium ion
response to purine-containing compound
response to corticosteroid
protein acylation
response to ketone
hormone metabolic process
protein maturation
response to insulin