ACAT2

Entrez Summary: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Thiolase N
Thiolase C

acetyl-CoA C-acetyltransferase activity
acetyl-CoA C-acyltransferase activity
cholesterol biosynthetic process
secondary alcohol biosynthetic process
sterol biosynthetic process
fatty acid beta-oxidation
fatty acid oxidation
lipid oxidation
fatty acid catabolic process
alcohol biosynthetic process
cholesterol metabolic process
monocarboxylic acid catabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
organic hydroxy compound biosynthetic process
cellular lipid catabolic process
lipid modification
steroid metabolic process
carboxylic acid catabolic process
organic acid catabolic process
lipid catabolic process
alcohol metabolic process
fatty acid metabolic process
small molecule catabolic process
organic hydroxy compound metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
nucleolus
carboxylic acid metabolic process
cellular lipid metabolic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
lipid metabolic process
mitochondrion
organic cyclic compound biosynthetic process
small molecule metabolic process
organic substance catabolic process