ACTA1

Entrez Summary: The product encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Mutations in this gene cause nemaline myopathy type 3, congenital myopathy with excess of thin myofilaments, congenital myopathy with cores, and congenital myopathy with fiber-type disproportion, diseases that lead to muscle fiber defects. [provided by RefSeq, Jul 2008].
UniProt Summary: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Wortmannin 5μM R00 exp38	1.71
Oligomycin-A 20μM R00 exp26	1.9

skeletal muscle fiber adaptation
mesenchyme migration
skeletal muscle adaptation
skeletal muscle thin filament assembly
skeletal myofibril assembly
striated muscle thin filament
response to lithium ion
myosin binding
skeletal muscle fiber development
myotube cell development
striated muscle adaptation
muscle adaptation
muscle filament sliding
ADP binding
actin-myosin filament sliding
sarcomere
mesenchyme morphogenesis
myotube differentiation
muscle fiber development
myofibril assembly
stress fiber
cell body
filopodium
actin filament
actin-mediated cell contraction
tissue migration
structural constituent of cytoskeleton
cellular component assembly involved in morphogenesis
actin filament-based movement
actomyosin structure organization
skeletal muscle tissue development
skeletal muscle organ development
striated muscle cell development
blood microparticle
muscle cell development
lamellipodium
striated muscle cell differentiation
response to mechanical stimulus
actin cytoskeleton
mesenchyme development