AGBL4

Entrez Summary: N/A
UniProt Summary: Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5. {ECO:0000250|UniProtKB:Q09LZ8}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Palbociclib 1μM R07 exp382	-1.86
BI-D1870 2μM R04 exp162	1.78

protein side chain deglutamylation
C-terminal protein deglutamylation
protein deglutamylation
C-terminal protein amino acid modification
metallocarboxypeptidase activity
peptidyl-glutamic acid modification
tubulin binding
ciliary basal body
centriole
defense response to virus
response to virus
post-translational protein modification
zinc ion binding
peptidyl-amino acid modification
defense response to other organism
Golgi apparatus
immune effector process
proteolysis
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response