AKR1B15

Entrez Summary: N/A
UniProt Summary: Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H) (PubMed:25577493). {ECO:0000269|PubMed:21276782, ECO:0000269|PubMed:25577493}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

farnesol dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
allyl-alcohol dehydrogenase activity
estradiol 17-beta-dehydrogenase activity
NADP-retinol dehydrogenase activity
alcohol dehydrogenase (NADP+) activity
alditol:NADP+ 1-oxidoreductase activity
estrogen biosynthetic process
estrogen metabolic process
retinol metabolic process
steroid hormone biosynthetic process
hormone biosynthetic process
primary alcohol metabolic process
retinoid metabolic process
diterpenoid metabolic process
oxidoreductase activity
terpenoid metabolic process
cellular hormone metabolic process
steroid biosynthetic process
isoprenoid metabolic process
hormone metabolic process
steroid metabolic process
alcohol metabolic process
mitochondrial matrix
organic hydroxy compound metabolic process
regulation of hormone levels
lipid biosynthetic process
cellular lipid metabolic process
oxidation-reduction process
lipid metabolic process
mitochondrion
organic cyclic compound biosynthetic process
small molecule metabolic process