ANKRD53

Entrez Summary: N/A
UniProt Summary: Required for normal progression through mitosis. Involved in chromosome alignment and cytokinesis via regulation of microtubules polymerization. {ECO:0000269|PubMed:26820536}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Ank
Ank 2

regulation of mitotic cytokinesis
positive regulation of microtubule polymerization
positive regulation of microtubule polymerization or depolymerization
regulation of mitotic spindle organization
regulation of spindle organization
mitotic metaphase plate congression
regulation of microtubule polymerization
metaphase plate congression
establishment of chromosome localization
chromosome localization
regulation of microtubule polymerization or depolymerization
regulation of cytokinesis
mitotic sister chromatid segregation
spindle
spindle pole
positive regulation of protein polymerization
sister chromatid segregation
mitotic nuclear division
regulation of cell division
regulation of microtubule cytoskeleton organization
positive regulation of supramolecular fiber organization
nuclear chromosome segregation
positive regulation of cytoskeleton organization
regulation of microtubule-based process
regulation of protein polymerization
positive regulation of protein complex assembly
chromosome segregation
nuclear division
organelle fission
regulation of supramolecular fiber organization
establishment of organelle localization
regulation of protein complex assembly
cell division
positive regulation of cellular component biogenesis
regulation of cytoskeleton organization
organelle localization
mitotic cell cycle process
positive regulation of organelle organization
regulation of mitotic cell cycle
mitotic cell cycle