ARHGAP4

• Official Symbol: ARHGAP4
• Official Name: Rho GTPase activating protein 4
• Aliases and Previous Symbols: N/A
• Entrez ID: 393
• UniProt: P98171
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
• UniProt Summary: Inhibitory effect on stress fiber organization. May down-regulate Rho-like GTPase in hematopoietic cells.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 10507
• Expression level (log2 read counts): 7.11

Expression Distribution

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ARHGAP4 Expression in NALM6 Cells: 7.11