ARHGEF16

Entrez Summary: N/A
UniProt Summary: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6. {ECO:0000269|PubMed:20679435}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Pimelic-diphenylamide-106 0.5μM R00 exp27	-1.87
Doxycycline 10μM R00 exp18	-1.79

Rho GTPase binding
positive regulation of protein localization to plasma membrane
receptor tyrosine kinase binding
positive regulation of protein localization to cell periphery
Rho guanyl-nucleotide exchange factor activity
PDZ domain binding
regulation of protein localization to plasma membrane
activation of GTPase activity
regulation of protein localization to cell periphery
positive regulation of protein localization to membrane
regulation of Rho protein signal transduction
regulation of protein localization to membrane
cell chemotaxis
regulation of Ras protein signal transduction
cadherin binding
positive regulation of cellular protein localization
regulation of small GTPase mediated signal transduction
positive regulation of GTPase activity
regulation of GTPase activity
regulation of cellular protein localization
chemotaxis
taxis
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
positive regulation of hydrolase activity
regulation of cellular localization
cell migration
regulation of protein localization
cell motility
localization of cell
regulation of hydrolase activity
locomotion
G protein-coupled receptor signaling pathway
positive regulation of catalytic activity
regulation of apoptotic process
movement of cell or subcellular component
regulation of programmed cell death
regulation of cell death
positive regulation of molecular function