ARHGEF39

Entrez Summary: N/A
UniProt Summary: Promotes cell proliferation. {ECO:0000269|PubMed:22327280}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rifampicin 10μM R00 exp32	-1.92
Rifampicin 1μM R00 exp31	-1.73

Rho guanyl-nucleotide exchange factor activity
regulation of Rho protein signal transduction
regulation of Ras protein signal transduction
regulation of small GTPase mediated signal transduction
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
regulation of cell migration
regulation of cell motility
regulation of locomotion
regulation of cellular component movement
regulation of intracellular signal transduction