ARID5A

Gene Information

Official Symbol: ARID5A
Official Name: AT-rich interaction domain 5A
Aliases and Previous Symbols: N/A
Entrez ID: 10865
UniProt: Q03989
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer- dependent gene expressison (PubMed:8649988). May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early- stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors (PubMed:15941852). As RNA- binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6- dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). {ECO:0000250|UniProtKB:Q3U108, ECO:0000269|PubMed:15941852, ECO:0000269|PubMed:8649988}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.1
Ribavirin 10 to 15μM on day4 R04 exp160	-1.85
Chloramphenicol 20μM R00 exp13	1.77
Zebularine 20μM R07 exp423	1.89
Beta-Estradiol 0.55μM R07 exp425	1.97
HMS-I1 1μM R01 exp46	2.16

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10997
Expression level (log2 read counts): 4.92

Expression Distribution

cellular response to estrogen stimulus
retinoid X receptor binding
thyroid hormone receptor binding
estrogen receptor binding
androgen receptor binding
response to estrogen
transcription regulatory region DNA binding
transcription corepressor activity
DNA-binding transcription repressor activity, RNA polymerase II-specific
transcription factor binding
sequence-specific DNA binding
innate immune response
nucleolus
negative regulation of transcription by RNA polymerase II
defense response to other organism
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
response to other organism
response to external biotic stimulus
response to biotic stimulus
negative regulation of RNA metabolic process
defense response
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression
immune response