ATG16L1

Entrez Summary: The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ATG16
WD40

negative stranded viral RNA replication
ubiquitin-like protein transferase activity
viral RNA genome replication
phagophore assembly site membrane
viral genome replication
autophagosome membrane
GTPase binding
autophagosome assembly
autophagosome organization
autophagosome
axoneme
vacuole organization
macroautophagy
viral life cycle
autophagy
process utilizing autophagic mechanism
protein homooligomerization
protein complex oligomerization
viral process
organelle assembly
symbiotic process
interspecies interaction between organisms
identical protein binding
protein transport
peptide transport
protein-containing complex assembly
amide transport
establishment of protein localization
cellular catabolic process
nitrogen compound transport
protein-containing complex subunit organization