ATP12A

Entrez Summary: N/A
UniProt Summary: Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for potassium absorption in various tissues.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nocodazole 0.1μM R03 exp94	-2.32
Oligomycin-A 2μM R00 exp25	-2
Epigallocatechin gallate 20μM R05 exp230	1.72
Tenofovir 10μM R07 exp405	1.74
DKK1 89ng/ml R08 exp477	1.77
NN-Dimethylsphingosine 2.5μM R08 exp508	1.86
ABT-702 5μM R06 exp261	1.99

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

potassium:proton exchanging ATPase complex
potassium:proton exchanging ATPase activity
sodium:potassium-exchanging ATPase activity
sodium ion export across plasma membrane
cellular potassium ion homeostasis
establishment or maintenance of transmembrane electrochemical gradient
cellular sodium ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
export across plasma membrane
potassium ion import across plasma membrane
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
sodium ion transmembrane transport
import across plasma membrane
regulation of pH
cellular monovalent inorganic cation homeostasis
monovalent inorganic cation homeostasis
proton transmembrane transport
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
basolateral plasma membrane
monovalent inorganic cation transport
cellular metal ion homeostasis
inorganic cation transmembrane transport
cation transmembrane transport
metal ion homeostasis
cellular cation homeostasis
metal ion transport
cellular ion homeostasis
inorganic ion transmembrane transport
import into cell
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cation transport
cellular homeostasis
ion transmembrane transport