ATXN3L

Entrez Summary: This intronless gene may be a pseudogene (PMID:11450850). This gene is similar to the multi-exon gene which encodes ataxin 3 and contains a coding region which could encode a protein similar to ataxin 3. Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease. [provided by RefSeq, Sep 2011].
UniProt Summary: Deubiquitinating enzyme that cleaves both 'Lys-48'- linked and 'Lys-63'-linked poly-ubiquitin chains (in vitro).

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

RNA polymerase II regulatory region DNA binding
monoubiquitinated protein deubiquitination
nuclear inclusion body
histone H3 deacetylation
cellular response to misfolded protein
exploration behavior
response to misfolded protein
histone deacetylase activity
protein quality control for misfolded or incompletely synthesized proteins
histone deacetylation
protein deacetylation
protein deacylation
macromolecule deacylation
cellular response to heat
mitochondrial membrane
thiol-dependent ubiquitin-specific protease activity
response to heat
cellular response to topologically incorrect protein
response to temperature stimulus
response to topologically incorrect protein
regulation of cell-substrate adhesion
protein deubiquitination
ubiquitin protein ligase binding
protein modification by small protein removal
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
histone modification
mitochondrial matrix
covalent chromatin modification
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
behavior
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
regulation of cell adhesion
protein catabolic process
chromatin organization
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal