B3GALT4

Entrez Summary: N/A
UniProt Summary: Involved in GM1/GD1B/GA1 ganglioside biosynthesis. {ECO:0000269|PubMed:9582303}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Dimethylsphingosine 2.5μM R08 exp508	-2.03
Mubritinib 0.2μM R01 exp48	-1.82
PNU96415E 10μM R03 exp145	-1.78
Thalidomide 20μM R07 exp406	1.81

ganglioside galactosyltransferase activity
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
ganglioside biosynthetic process
ganglioside metabolic process
acetylgalactosaminyltransferase activity
glycosphingolipid biosynthetic process
ceramide biosynthetic process
glycolipid biosynthetic process
glycosphingolipid metabolic process
ceramide metabolic process
sphingolipid biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
amide biosynthetic process
lipid biosynthetic process
carbohydrate derivative biosynthetic process
Golgi membrane
cellular amide metabolic process
cellular lipid metabolic process
Golgi apparatus
endoplasmic reticulum
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process