B4GALT6
Gene Information
- Official Symbol: B4GALT6
- Official Name: beta-1,4-galactosyltransferase 6
- Aliases and Previous Symbols: N/A
- Entrez ID: 9331
- UniProt: Q9UBX8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Required for the biosynthesis of glycosphingolipids. {ECO:0000269|PubMed:1551920, ECO:0000269|PubMed:3099851}.
Pfam Domains GO Terms
Pfam Domains
| Galactosyl T 2 |
GO Terms
| lactosylceramide biosynthetic process |
| lactosylceramide metabolic process |
| ganglioside biosynthetic process via lactosylceramide |
| UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity |
| ganglioside biosynthetic process |
| galactosyltransferase activity |
| ganglioside metabolic process |
| axon ensheathment in central nervous system |
| central nervous system myelination |
| glycosphingolipid biosynthetic process |
| keratan sulfate biosynthetic process |
| keratan sulfate metabolic process |
| central nervous system neuron axonogenesis |
| neuron maturation |
| oligodendrocyte development |
| ceramide biosynthetic process |
| glycosphingolipid metabolic process |
| glycolipid biosynthetic process |
| oligodendrocyte differentiation |
| central nervous system neuron development |
| ceramide metabolic process |
| sphingolipid biosynthetic process |
| Golgi cisterna membrane |
| glycosaminoglycan biosynthetic process |
| myelination |
| mucopolysaccharide metabolic process |
| glial cell development |
| axon ensheathment |
| ensheathment of neurons |
| aminoglycan biosynthetic process |
| glycolipid metabolic process |
| liposaccharide metabolic process |
| membrane lipid biosynthetic process |
| anatomical structure maturation |
| sphingolipid metabolic process |
| glycosaminoglycan metabolic process |
| cell maturation |
| aminoglycan metabolic process |
| glial cell differentiation |
| central nervous system neuron differentiation |
| sulfur compound biosynthetic process |
| membrane lipid metabolic process |
| gliogenesis |
| developmental maturation |
| protein glycosylation |
| macromolecule glycosylation |
| glycosylation |
| glycoprotein biosynthetic process |
| sulfur compound metabolic process |
| axonogenesis |
| glycoprotein metabolic process |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| carbohydrate metabolic process |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| amide biosynthetic process |
| cell morphogenesis involved in differentiation |
| lipid biosynthetic process |
| Golgi membrane |
| carbohydrate derivative biosynthetic process |
| neuron projection development |
| cell morphogenesis |
| cellular amide metabolic process |
| neuron development |
| cellular component morphogenesis |
| cellular lipid metabolic process |
| central nervous system development |
| oxoacid metabolic process |
| neuron differentiation |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| lipid metabolic process |
| organonitrogen compound biosynthetic process |
| generation of neurons |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| cell development |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-D1870 3.15μM R02 exp66 | -2.26 |
| PNU96415E 10μM R03 exp145 | -1.99 |
| Pyridostatin 4μM R05 exp240 | -1.71 |
| Menadione 5μM R06 exp292 | 1.71 |
| ABT-702 5μM R07 exp318 | 1.74 |
| BI-6727 0.04μM R03 exp98 | 1.76 |
| GSK591 2.6μM R03 exp128 | 2 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 17153
- Expression level (log2 read counts): 3.11
Expression Distribution
B4GALT6 Expression in NALM6 Cells: 3.11
