BANK1

Gene Information

Official Symbol: BANK1
Official Name: B cell scaffold protein with ankyrin repeats 1
Aliases and Previous Symbols: N/A
Entrez ID: 55024
UniProt: Q8NDB2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a B-cell-specific scaffold protein that functions in B-cell receptor-induced calcium mobilization from intracellular stores. This protein can also promote Lyn-mediated tyrosine phosphorylation of inositol 1,4,5-trisphosphate receptors. Polymorphisms in this gene are associated with susceptibility to systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
UniProt Summary: Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2. {ECO:0000269|PubMed:11782428}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7994
Expression level (log2 read counts): -0.22

Expression Distribution

Screen	Score
Golgicide-A 2μM R03 exp121	1.73
UNC2400 2μM R03 exp156	1.74
NFN1 0.1μM R01 exp49	1.76

negative regulation of interleukin-6 secretion
negative regulation of translational initiation
protein tyrosine kinase binding
negative regulation of B cell activation
negative regulation of interleukin-6 production
negative regulation of protein kinase B signaling
negative regulation of cytokine secretion
regulation of translational initiation
negative regulation of translation
negative regulation of protein secretion
negative regulation of peptide secretion
regulation of interleukin-6 production
negative regulation of lymphocyte activation
negative regulation of cellular amide metabolic process
B cell activation
negative regulation of leukocyte activation
negative regulation of protein transport
negative regulation of establishment of protein localization
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of cell activation
negative regulation of secretion by cell
regulation of cytokine secretion
regulation of B cell activation
regulation of protein kinase B signaling
negative regulation of secretion
regulation of peptidyl-tyrosine phosphorylation
negative regulation of cytokine production
signaling receptor binding
regulation of translation
lymphocyte activation
regulation of cellular amide metabolic process
negative regulation of immune system process
regulation of protein secretion
negative regulation of transport
regulation of peptide secretion
negative regulation of intracellular signal transduction
regulation of lymphocyte activation
posttranscriptional regulation of gene expression
positive regulation of MAPK cascade
regulation of leukocyte activation