BLOC1S5

Entrez Summary: N/A
UniProt Summary: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. {ECO:0000269|PubMed:17182842}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Curcumin 6.5μM R06 exp277	1.72
Arsenate 40μM R06 exp264	1.8

positive regulation of pigment cell differentiation
regulation of pigment cell differentiation
positive regulation of developmental pigmentation
endosome to pigment granule transport
pigment granule maturation
endosome to melanosome transport
pigment accumulation
cellular pigment accumulation
regulation of developmental pigmentation
synaptic vesicle transport along microtubule
anterograde synaptic vesicle transport
synaptic vesicle cytoskeletal transport
BLOC-1 complex
melanosome transport
pigment granule transport
establishment of melanosome localization
establishment of pigment granule localization
melanosome organization
melanosome localization
pigment granule localization
pigment granule organization
pigment cell differentiation
synaptic vesicle transport
developmental pigmentation
synaptic vesicle localization
vesicle transport along microtubule
anterograde axonal transport
cellular pigmentation
vesicle cytoskeletal trafficking
axonal transport
axon cytoplasm
axo-dendritic transport
organelle transport along microtubule
pigmentation
transport vesicle
transport along microtubule
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
vesicle localization