BRAT1

Entrez Summary: The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 60/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	0/28
bone	4/26
breast	5/33
central nervous system	6/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	3/16
kidney	6/21
liver	2/20
lung	7/75
lymphocyte	1/16
ovary	4/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	1/2
upper aerodigestive	3/22
urinary tract	4/29
uterus	0/5

Expression Distribution

mitochondrion localization
glucose metabolic process
response to ionizing radiation
hexose metabolic process
positive regulation of cell growth
monosaccharide metabolic process
positive regulation of growth
regulation of cell growth
response to radiation
carbohydrate metabolic process
cell population proliferation
organelle localization
regulation of growth
cellular response to DNA damage stimulus
apoptotic process
cell migration
positive regulation of protein phosphorylation
programmed cell death
positive regulation of phosphorylation
cell motility
localization of cell
cell death
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
response to abiotic stimulus
positive regulation of protein modification process
locomotion
regulation of protein phosphorylation
movement of cell or subcellular component
regulation of phosphorylation
positive regulation of cellular protein metabolic process
cellular response to stress
positive regulation of protein metabolic process
small molecule metabolic process
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of protein modification process
membrane